This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in this journal  Topic Collections  • Bacterial Infections  • HIV/AIDS  • Sexually Transmitted Diseases  • Dermatologic Disorders  • Diagnosis  • Dermatologic Disorders, Other  • Dermatology, Other  • Alert me on articles by topic  Social Bookmarking   What's this?

Arch Dermatol. 2009;145(7):829-834.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Malignant syphilis (lues maligna).

MICROSCOPIC FINDINGS AND CLINICAL COURSE

Histopathologic examination of the specimen showed an ulcerated papule with crust overlying a follicle. In the superficial and deep dermis, a dense periadnexal and perivascular cell infiltrate extending up to the dermoepidermal junction was observed (Figure 2). This infiltrate was predominantly composed of lymphocytes, histiocytes, scanty neutrophils, and plasma cells. Vessels in the dermis appeared congested and showed prominent endothelial cells (Figure 3). Spirochetes were demonstrated by Whartin-Starry stain (Figure 3, inset).

Figure appears in full text version. Figure 2.

Figure appears in full text version. Figure 3.

Serologic testing was positive for lues (rapid plasma reagin test, a titer of 1:16; Treponema pallidum particle agglutination assay, a titer of <1:20 480). The patient responded rapidly to treatment with penicillin G benzathine (2.4 million IUs administered by intramuscular injection once a week for 3 weeks) with remittance of the skin lesions and fever.

DISCUSSION

Malignant syphilis is an unusual ulcerative variant of secondary syphilis that has been more . . . [Full Text of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

RELATED ARTICLE

Generalized Ulcerated Nodules in a Patient With Human Immunodeficiency Virus Infection—Quiz Case
Mar Blanes, Francisca María Peiró, Concepción Benito, and Isabel Belinchón
Arch Dermatol. 2009;145(7):829-834.
EXTRACT | FULL TEXT