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Rachael Jarrett, BMBCh; Lisa Walker, BMBCh, BSc, DPhil, MRCPCH; Jonathan Bowling, MBChB, MRCP
Oxford Radcliffe Hospitals (Dr Jarrett) and Churchill Hospital (Drs Walker and Bowling), Oxford, England

Arch Dermatol. 2009;145(7):854.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

We describe 2 patients with known mutations in the CYLD-1 gene (OMIM 123850) who were seen in the skin cancer genetics clinic to illustrate the dermoscopic appearance of cylindromas in Brooke-Spiegler syndrome. Case 1 involved a 42-year-old woman with multiple firm, rubbery, pink nodules with areas of hyperpigmentation and telangiectasia (Figure 1). Case 2 involved a 45-year-old woman with multiple fleshy dermal nodules, some of which were erythematous with surface telangiectasia (Figure 2). Dermoscopy showed areas of background pink coloration with ill-defined arborizing vessels and ill-defined blue structures (case 1, Figure 3; case 2, Figure 4). Histologic analysis revealed features that were intermediate between a cylindroma and a spiradenoma in case 1 and consistent with cylindromas in case 2. Brooke-Spiegler syndrome is characterized by a predisposition to cutaneous adnexal tumors, . . . [Full Text of this Article]

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