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Arch Dermatol. 2009;145(8):931-936.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Tuberculosis cutis orificialis (TCO).

MICROSCOPIC FINDINGS AND CLINICAL COURSE

Histologic examination showed psoriasiform hyperplasia with confluent parakeratosis. Within the dermis were granulomatous infiltrates composed of histiocytes, epithelioid cells, and Langhans giant cells mixed with aggregates of neutrophils and perivascular lymphocytic inflammation.

Findings of polymerase chain reaction testing for Mycobacterium tuberculosis DNA from the skin biopsy specimen were positive. The results of acid-fast bacilli culture from the skin biopsy specimen and the Mantoux test were negative. Chest radiography did not show any focal lung infiltrates or fibrosis. Findings of proctoscopy and computed tomography of the abdomen and pelvis were normal. Analysis of sputum smears and cultures found no acid-fast bacilli.

The patient was treated with daily doses of rifampicin, 600 mg; isoniazid, 300 mg; ethambutol, 800 mg; pyrazinamide, 1g, for 8 weeks followed by rifampicin and isoniazid treatment for 4 months. Complete resolution of the ulcers occurred within 1 month of initiation of therapy.

DISCUSSION

Tuberculosis cutis orificialis is a rare . . . [Full Text of this Article]

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