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Arch Dermatol. 2009;145(9):1053-1058.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Argyria.

MICROSCOPIC FINDINGS AND CLINICAL COURSE

On low power, the punch biopsy specimen showed no apparent findings. On x100 power, using oil immersion, numerous fine black granules were seen within the sebaceous gland basement membrane, capillary walls, and arrector pili muscle (Figure 2). The granules were also noted prominently in elastic fibers but not in the collagen bundles (Figure 3). The patient began taking selenium supplementation (200 µg/d) for 2 months. After noticing no improvement, he decided to discontinue all therapies and interventions. After 6 months, his skin was largely unchanged.

Figure appears in full text version. Figure 2.

Figure appears in full text version. Figure 3.

DISCUSSION

Argyria is a blue-gray or slate pigmentation of the skin, resulting from silver deposition. It can manifest as either a localized or a generalized form,¹ with the latter being more common.² Localized argyria is most frequently caused by occupational exposure and is commonly seen in miners and jewelers.² Generalized argyria mainly results from the systemic distribution . . . [Full Text of this Article]

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