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Clear Cell Papulosis: A Connection of Clear Cells to Toker Cells or Paget Disease
Yue Yu, MD, PhD;
Smita Sukhatme, BS;
Daniel S. Loo, MD
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Report of a Case
A 1-year-old healthy Asian American girl presented with a 4-month history of white spots, increasing in number and size, in the inguinal and buttocks region. Physical examination revealed numerous 3- to 8-mm oval, hypopigmented macules and flat-topped papules in the suprapubic (Figure 1), genital, and buttocks regions. Similar lesions were scattered over the chest and bilateral axilla. Hair, nails, and teeth were normal.
Figure appears in full text version.
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Figure 1. Multiple hypopigmented macules and flat-topped papules in the suprapubic area.
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A skin biopsy specimen revealed mild epidermal hyperplasia with clear cells scattered predominantly around basal keratinocytes (Figure 2A). Immunohistochemically, the clear cells stained positive for cytokeratin 7 (CK-7) (Figure 2B), cell adhesion molecule 5.2 (CAM-5.2), carcinoembryonic antigen (CEA), keratins AE-1 and AE-3, epithelial membrane antigen (EMA), and gross cystic disease fluid protein 15; the cells also showed positive . . . [Full Text of this Article]
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
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Clear Cell Papulosis of the Skin: Acquired Hypomelanosis
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Arch Dermatol 2011;147:128-129.
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