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  Vol. 145 No. 9, September 2009 TABLE OF CONTENTS
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VIGNETTES
Acute Generalized Exanthematous Pustulosis Caused by Rifabutin

Chih-Pin Chen, MD; Yung-Hsiang Hsu, MD; Song-Jen Hong, MD

Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Acute generalized exanthematous pustulosis (AGEP), first named by Beylot et al1 in 1980, is a clinical reaction pattern that is principally drug induced.2-3 Its incidence is probably underestimated because many cases are either unrecognized or confused with pustular psoriasis.3 We report herein a case of AGEP caused by rifabutin, an antituberculous agent.

Report of a Case

A 58-year-old man with hypertension, coronary artery disease, and schizophrenia was admitted to our hospital for cervical nontuberculous mycobacterial lymphadenitis. He had a history of drug allergy to trimethoprim-sulfamethoxazole presenting as a generalized nonpustular exanthematous eruption. After 10 days of treatment with rifabutin, he developed a fever with temperatures up to 38°C accompanied by numerous nonfollicular sterile pustules on widespread edematous erythema over the trunk and all extremities without mucous membrane involvement (Figure 1).


 
Figure appears in full text version.
Figure 1. Numerous nonfollicular pinhead sterile pustules on edematous and erythematous plaques over . . . [Full Text of this Article]



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