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VIGNETTES
Acute Generalized Exanthematous Pustulosis Caused by Rifabutin
Chih-Pin Chen, MD;
Yung-Hsiang Hsu, MD;
Song-Jen Hong, MD
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Acute generalized exanthematous pustulosis (AGEP), first named by Beylot et al1 in 1980, is a clinical reaction pattern that is principally drug induced.2-3 Its incidence is probably underestimated because many cases are either unrecognized or confused with pustular psoriasis.3 We report herein a case of AGEP caused by rifabutin, an antituberculous agent.
Report of a Case
A 58-year-old man with hypertension, coronary artery disease, and schizophrenia was admitted to our hospital for cervical nontuberculous mycobacterial lymphadenitis. He had a history of drug allergy to trimethoprim-sulfamethoxazole presenting as a generalized nonpustular exanthematous eruption. After 10 days of treatment with rifabutin, he developed a fever with temperatures up to 38°C accompanied by numerous nonfollicular sterile pustules on widespread edematous erythema over the trunk and all extremities without mucous membrane involvement (Figure 1).
Figure appears in full text version.
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Figure 1. Numerous nonfollicular pinhead sterile pustules on edematous and erythematous plaques over . . . [Full Text of this Article]
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