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Angioma Serpiginosum
A Report of 2 Cases Identified Using Epiluminescence Microscopy
Takamitsu Ohnishi, MD, PhD;
Takashi Nagayama, MD;
Takashi Morita, MD;
Takako Miyazaki, MD;
Hiroyuki Okada, MD;
Kuniaki Ohara, MD;
Shinichi Watanabe, MD, PhD
Arch Dermatol. 1999;135:1366-1368.
ABSTRACT
Background Angioma serpiginosum is a rare, acquired vascular lesion simulating purpura, and should be differentiated from purpuric dermatoses such as Henoch-Schönlein purpura.
Observations We report 2 cases of angioma serpiginosum examined using epiluminescence microscopy. Characteristic findings of angiomas ("red lagoons") were observed entirely or focally in these 2 cases, but not in 4 cases of Henoch-Schönlein purpura and a case of senile purpura.
Conclusion Epiluminescence microscopy is beneficial in distinguishing angioma serpiginosum from purpuric dermatoses.
INTRODUCTION
ANGIOMA serpiginosum is a rare acquired vascular disorder that manifests clinically as numerous punctate erythemas that simulate purpura. Therefore, it is sometimes difficult to distinguish from purpuric dermatoses such as Henoch-Schönlein purpura. We report 2 cases of angioma serpiginosum diagnosed using epiluminescence microscopy.
METHODS
The eruptions were evaluated in vivo with application of Echo Gel (Nikko Fine Industries Co Ltd, Tokyo, Japan) using a Dermatoscope Delta 10 (Heine Optotechnik, Herrsching, Germany), and were photographed using Dermaphoto (Heine Optotechnik, Herrsching, Germany). For comparison, 4 cases of Henoch-Schönlein purpura (histologically confirmed as leukocytoclastic vasculitis) were analyzed by the same procedure. A case of senile purpura was also examined.
REPORT OF CASES
CASE 1
A 21-year-old woman came to our department in October 1998 with an asymptomatic eruption on her knee that had been noticed about 5 years previously. The lesion had not grown or multiplied since that time. The patient's medical and family histories were unremarkable. The findings of physical examination included numerous punctate, dark red erythemas around her right knee that did not disappear under the pressure of diascopy (Figure 1).
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Figure 1. Case 1. Numerous punctate, dark red erythemas are present around the knee and do not disappear under the pressure of diascopy.
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CASE 2
In August 1998, a 15-year-old boy presented with punctate eruptions on his right lower extremity. His parents had first noticed the eruptions about 4 months after his birth, although there were no eruptions present at birth. They gradually multiplied with no symptomatic sign until about age 7 years. The patient's medical and family histories were unremarkable. Findings of physical examination included numerous punctate erythemas on the lateral portion of the leg from the right knee to the lower leg, some of which were grouped (Figure 2). The eruptions did not disappear under diascopy.
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Figure 2. Case 2. Numerous punctate erythemas, some of which are grouped on the lateral region of the lower extremity.
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HISTOPATHOLOGIC FINDINGS
The results of histopathologic examinations in both cases revealed dilated, thin-walled capillaries in the dermal papillae and superficial reticular dermis. There was no extravasation of red blood cells and no perivascular inflammatory infiltration (Figure 3).
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Figure 3. Case 2. Histopathologic findings. Of note is the dilated, thin-walled capillary in the dermal papilla (hematoxylin-eosin, original magnification x50).
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RESULTS
In case 1 the condition manifested entirely as numerous small, red, sharply demarcated lagoons (Figure 4). In case 2, the results of epiluminescence microscopy showed relatively well-demarcated round to oval red patches, including the typical red lagoon (Figure 5). In the 4 cases of Henoch-Schönlein purpura and a case of senile purpura, however, the eruptions consisted of irregularly shaped red patches with blurred borders; no lagoon was observed.
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Figure 4. Case 1. Epiluminescence microscopy findings. The eruptions consist exclusively of numerous small, red, sharply demarcated lagoons.
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Figure 5. Case 2. Epiluminescence microscopic findings. Relatively well-demarcated round to oval red patches, including the typical red lagoons.
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COMMENT
Angioma serpiginosum is characterized by erythematous punctate lesions that do not disappear under diascopy.1 Because the lesion simulates purpura, differentiation from purpuric dermatoses such as Henoch-Schönlein purpura is important, and it is sometimes difficult to distinguish them by clinical appearance alone. Therefore, the patient with angioma serpiginosum tends to undergo unnecessary hematological tests for the investigation of purpura.2
Epiluminescence microscopy is a nonstressful procedure for evaluating colored lesions of the skin surface. There have been many investigations concerning melanocytic lesions,3 especially malignant melanoma.4 However, the procedure is also useful for evaluating vascular lesions. Typical findings, ie, demarcated red lagoons due to dilated vascular spaces within the papillary or superficial reticular dermis, occur in hemangiomas, predominantly in eruptive hemangiomas and angiokeratomas.5 To the best of our knowledge, there is no report of epiluminescence microscopy being used to evaluate angioma serpiginosum. The eruptions in case 1 consisted entirely of red lagoons, and those in case 2 included red lagoons as well as other hemangiomas; there were no lagoons in the 5 cases of purpuric lesions. Therefore, epiluminescence microscopy is beneficial in distinguishing angioma serpiginosum from purpuric dermatoses.
AUTHOR INFORMATION
Accepted for publication June 24, 1999.
Reprints: Takamitsu Ohnishi, MD, Department of Dermatology, Teikyo University School of Medicine, 11-1, Kaga-2, Itabashi-ku, Tokyo 173-8605, Japan (e-mail: ohnishi{at}med.teikyo-u.ac.jp).
From the Departments of Dermatology, Teikyo University School of Medicine (Drs Ohnishi, Nagayama, Morita, Miyazaki, Okada, and Watanabe) and Toranomon Hospital (Dr Ohara), Tokyo, Japan.
REFERENCES
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1. Barker LP, Sachs PM. Angioma serpiginosum. Arch Dermatol. 1965;92:613-620.
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2. Cox NH, Paterson WD. Angioma serpiginosum: a simulator of purpura. Postgrad Med J. 1991;67:1065-1066.
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3. Argenziano G, Fabbrocini G, Carli P, De Giorgi V, Sammarco E, Delfino M. Epiluminescence microscopy for the diagnosis of doubtful melanocytic skin lesions. Arch Dermatol. 1998;134:1563-1570.
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4. Menzies SW, Ingvar C, Crotty KA, McCarthy WH. Frequency and morphologic characteristics of invasive melanomas lacking specific surface microscopic features. Arch Dermatol. 1996;132:1178-1182.
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5. Stolz W, Falco OB, Bilek P, Landthaler M, Cognetta AB. Dermatoscopic criteria. In: Stolz W, Falco OB, Bilek P, Landthaler M, Cognetta AB, eds. Color Atlas of Dermatoscopy. Oxford, England: Blackwell Publishers; 1994:11-36.
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