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This Month in Archives of Dermatology
Arch Dermatol. 2002;138:15.
Treatment of Scleroderma
Systemic sclerosis (scleroderma) affects many organ systems, and skin
findings are often the most immediately visible. Treating systemic sclerosis
remains an immense clinical challenge. Sapadin and Fleischmajer critically
analyze the conventional as well as the new therapeutic approaches to this
condition that are directed toward improving circulation, preventing the synthesis
and release of harmful cytokines, and inhibiting or reducing fibrosis.
(SEE ARTICLE)
Amyopathic Dermatomyositis: A Review by the Italian Group of Immunodermatology
Dermatomyositis is a relatively rare connective tissue disease that
often presents with characteristic dermatologic findings. In the absence of
inflammatory myopathy, patients are considered to have amyopathic dermatomyositis.
In this retrospective analysis of 13 such patients, the clinical features
and serum immunologic findings support an overall favorable prognosis.
(SEE ARTICLE)
Concordance Between Telepathologic Diagnosis and Conventional Histopathologic
Diagnosis: A Multiobserver, Store-and-Forward Study on 20 Skin Specimens
Telepathology may be defined as the practice of pathology at a distance.
This is most often accomplished by visualizing an electronically transmitted
digital image on a monitor instead of viewing the specimen directly through
a microscope. In this study using 20 skin biopsy specimens, Piccolo et al
demonstrate concordance between diagnoses made after conventional glass slide
evaluation and those rendered after evaluation of digital images.
(SEE ARTICLE)
Efficacy of Itraconazole in the Prophylactic Treatment of Pityriasis
(Tinea) Versicolor
Tinea versicolor may be successfully treated with a variety of topical
or systemic medications; however, recurrence rates are unfortunately quite
high. Faergemann et al demonstrate that prophylactic therapy with 400 mg of
itraconazole once monthly is an effective and safe maintenance or prophylactic
regimen to prevent these recurrences.
(SEE ARTICLE)
 The Combined Continuous-Wave/Pulsed Carbon Dioxide Laser for Treatment
of Pyogenic Granuloma
Pyogenic granuloma is a common, benign vascular tumor. Various treatment
methods have been described, including excision, curettage, cryotherapy, chemical
and electrical cauterization, and a variety of laser techniques. In this prospective
study, Raulin et al demonstrate the safety and efficacy of the combined use
of the continuous-wave and pulsed carbon dioxide lasers for treating pyogenic
granuloma.
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A, Patient with pyogenic granuloma on the lower lip. B, Same patient
7 weeks after a single therapy session with the continuous-wave/pulsed carbon
dioxide laser. The lesion has healed completely with only slight textural
changes.
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(SEE ARTICLE)
Melanocytic Proliferations Associated With Lichen Sclerosus
Lichen sclerosus (LS) is a chronic inflammatory dermatosis that may
cause intractable itching and destructive scarring. The classic lesions of
LS have a white, depigmented, or vitiligolike appearance, although pigmentation
is present on rare occasions. Melanocytic nevi may be superimposed on lesions
of LS, and melanoma may even arise in the background of LS. Carlson et al
describe the key histologic features that can be used to confidently separate
LS melanocytic nevi from malignant melanoma.
(SEE ARTICLE)
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