Figure 2. Case 2, an 80-year-old man. A, Broad, irregularly pigmented macule 24 mm in maximum diameter on the sole of his foot. B, Dermoscopic image showing the typical parallel ridge pattern (original magnification, x20). C, Histopathologic image showing proliferation of atypical melanocytes in the epidermis, consistent with the diagnosis of melanoma in situ (hematoxylin-eosin, original magnification x200). D, Fluorescence in situ hybridization image showing multiple red CCND1 signals with 2 green reference signals in an atypical melanocyte (white arrow).