Figure 3. Case 10, a 60-year-old woman. A, Light brown macule on the sole of her foot. Maximal diameter of this lesion is only 6 mm. B, Dermoscopic image showing the typical parallel ridge pattern (original magnification x20). C, Histopathologic image showing a very slight increase of healthy-looking melanocytes along the basal layer (hematoxylin-eosin, original magnification x200). D, Fluorescence in situ hybridization image showing the CCND1 amplification in a melanocyte (white arrow) within the basal cell layer of the epidermis. Clustered and multiple red CCND1 signals are seen (inset).