Figure 2. Patient 4 with lentigo maligna. A, Lentigo maligna on the forehead. B, Large erosive lesion after 4 weeks of treatment with 5% imiquimod cream at the application site. C, Histopathologic findings of the erosive lesion during treatment; a superficial ulcer with a dense inflammatory infiltrate is present (hematoxylin-eosin, original magnification x50). D, Immunohistologic investigations showed predominance of T lymphocytes (CD3) with both helper (CD4) and cytotoxic (CD8, T-cell intracellular antigen 1 [TIA-1]) phenotypes (immunoperoxidase, original magnification x400).