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A Call for Papers for On the Horizon
Gary S. Wood, MD, Section Editor
Arch Dermatol. 2007;143(2):253-254.
In this issue of the ARCHIVES, Woodley1 discusses new advances in our understanding of the pathogenesis of bullous pemphigoid (BP). He uses the On the Horizon section to highlight a recent study by Fairley et al2 on the role of IgE class autoantibodies in this disorder. As he notes, there is now evidence that IgE autoantibodies directed against the NC-16A domain of BP180/type XVII collagen in the basal keratinocyte hemidesmosome can mediate mast cell degranulation and eosinophil chemotaxis. These findings are important because they provide a mechanistic basis for the pruritus, urticaria, and eosinophilic spongiosis that typify early BP clinicopathologically. They are also important because they suggest new approaches for the treatment of this vexing condition.
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Section Editor and Assistant Section Editors, On the Horizon
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On the Horizon is designed precisely for this purpose: To showcase a recent finding in the scientific literature that is likely to have a significant impact on our understanding of skin disease pathogenesis and ultimately contribute to more effective disease management. While treatment is an obvious focal point, other elements of improved disease management might include prevention, counseling, and public policy.
Like Woodley's article, On the Horizon is intended to have a concise, consistent structure. It begins with an abstract reprinted from the scientific literature that represents the focus of the article. This is followed by a short commentary of approximately 500 words and a few relevant references. If crucial to the message, 1 or 2 figures or tables might be included. The intent is to keep the content focused and contained to a single page of the ARCHIVES. We want each article to be easily absorbed during a brief coffee break or a quick lunch. They are designed to be habit forming—short and sweet.
A group of assistant section editors forms an advisory board and assists me with topic selection and editorial duties. The assistant section editors are Craig A. Elmets, MD (Birmingham, Ala), Molly A. Hinshaw, MD (Madison, Wis), Jay C. Klemme, MD, MPH (Wooster, Ohio), Mark R. Pittelkow, MD (Rochester, Minn), Martin A. Weinstock, MD, PhD (Providence, RI), and David T. Woodley, MD (Los Angeles, Calif). These individuals represent a geographically and professionally diverse group of dermatologists linked by a shared appreciation for scientific discovery and passion for translating new information into clinical practice.
However, if we are going to achieve our goal of making On the Horizon a monthly feature of the ARCHIVES, then we need your help. We know that excitement about advances in dermatology is shared by many dermatologists in and out of academics, as well as fellows, residents, and students. We invite all kindred spirits to submit material to On the Horizon. This is an excellent opportunity for residency program directors and other faculty mentors to get their trainees involved in writing about, not just reading about, scientific advances relevant to dermatology. Submissions may go directly to me or through one of the assistant section editors. We are more than happy to consult with you regarding the selection of potential abstracts and the composition of the commentary.
AUTHOR INFORMATION
Correspondence: Dr Wood, Department of Dermatology, University of Wisconsin, One South Park, Seventh Floor, Madison, WI 53715 (gwood{at}dermatology.wisc.edu).
REFERENCES
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1. Woodley DT. The role of IgE anti–basement membrane zone autoantibodies in bullous pemphigoid. Arch Dermatol. 2007;143:249-250.
FREE FULL TEXT
2. Fairley JA, Fu CL, Giudice GJ. Mapping the binding sites of BP180 IgE autoantibodies in bullous pemphigoid. J Invest Dermatol. 2005;125:467-472.
FULL TEXT
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