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VIGNETTES
Efficacy and Safety of 5% Imiquimod Cream in Treating Patients With Multiple Superficial Basal Cell Carcinomas
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There has been increasing interest in the use of 5% imiquimod cream in the treatment of patients with superficial basal cell carcinomas (sBCCs). To date, the reports of its efficacy apply to single tumors in individuals.1-3 However, in clinical practice it is common for patients to have more than 1 sBCC when they present for treatment.4 The aim of this study was to assess the safety and efficacy of 2 dosing regimens of 5% imiquimod cream for the treatment of patients with multiple sBCCs.
Methods and Results
Sixty-seven adults with a total of 208 histologically confirmed sBCCs on their trunk, limbs, or neck (2-6 tumors per person) applied 5% imiquimod cream 7 times per week or 5 times per week for 6 weeks. Twelve weeks after treatment, the tumor sites were examined clinically and histologically for evidence of residual tumor.
Sixty subjects (90%) had 2 to 4 target tumors. One hundred sixty-one tumors . . . [Full Text of this Article] Comment
Robin Marks, MBBS;
Mary Owens, MD;
Shelley-Ann Walters for the Australasian Multi-Centre Trial Group
Correspondence: Dr Marks, Department of Dermatology, University of Melbourne, St Vincent's Hospital, Fitzroy, Victoria 3065, Australia (jossr@svhm.org.au).
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
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Arch Dermatol 2005;141:985-993.
ABSTRACT
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