 |
|
Relationship Between Smoking and the Clinical Severity of Psoriasis
Cristina Fortes, PhD;
Simona Mastroeni, MSc;
Karen Leffondré, PhD;
Francesca Sampogna, MSc;
Franco Melchi, MD;
Eva Mazzotti, MSc;
Paolo Pasquini, MD, MPH;
Damiano Abeni, MD, MPH; for the IDI Multipurpose Psoriasis Research on Vital Experiences (IMPROVE) Study Group
Arch Dermatol. 2005;141:1580-1584.
Objective To evaluate the association between different components of smoking history and the clinical severity of psoriasis.
Design A hospital-based cross-sectional study.
Setting Inpatient wards of a hospital for skin diseases in Rome, Italy.
Patients A total of 818 adults with psoriasis.
Main Outcome Measure The Psoriasis Area and Severity Index was used to assess the clinical severity of psoriasis between February 21, 2000, and February 19, 2002.
Results After adjustment for potential confounders (sex, age, body mass index, psychological distress, family history of psoriasis, duration of psoriasis disease, and alcohol consumption), high intensity of smoking (>20 cigarettes daily) vs a lower level of consumption ( 10 cigarettes daily) was associated with a more than 2-fold increased risk of clinically more severe psoriasis (odds ratio [OR], 2.2; 95% confidence interval [CI], 1.2-4.1). Cigarette-years, measured as the product of the intensity and duration (years) of smoking, significantly increased the risk of clinically more severe psoriasis after adjustment for confounding factors (OR,1.3; 95% CI, 1.0-1.6, for a 600-U increase in cigarette-years). Separate analyses for men and women showed that the effect of cigarette-years was stronger for women (OR, 1.8; 95% CI, 1.2-2.6, for a 400-U increase in cigarette-years) than for men (OR, 1.2; 95% CI, 0.9-1.6, for a 700-U increase in cigarette-years).
Conclusion Smoking is associated with the clinical severity of psoriasis and highlights the importance of smoking cessation in patients with psoriasis.
Author Affiliations: Clinical Epidemiology Unit (Drs Fortes and Pasquini and Mss Mastroeni and Mazzotti), Health Service Unit (Ms Sampogna and Dr Abeni), and Dermatology Unit (Dr Melchi), Istituto Dermopatico dell'Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy; and Département de Médecine Sociale et Préventive and Axe Santé des Populations, Centre de Recherche du Centre Hospitalier, Université de Montréal, Montréal, Québec (Dr Leffondré).
RELATED ARTICLES
Obesity, Smoking, and Psoriasis
Mark Lebwohl and Jeffrey P. Callen
JAMA. 2006;295(2):208-210.
EXTRACT
| FULL TEXT
Impact of Obesity and Smoking on Psoriasis Presentation and Management
Mark D. Herron, Michael Hinckley, Matthew S. Hoffman, Jason Papenfuss, Christopher B. Hansen, Kristina P. Callis, and Gerald G. Krueger
Arch Dermatol. 2005;141(12):1527-1534.
ABSTRACT
| FULL TEXT
Prevalence and Treatment of Psoriasis in the United Kingdom: A Population-Based Study
Joel M. Gelfand, Rachel Weinstein, Steven B. Porter, Andrea L. Neimann, Jesse A. Berlin, and David J. Margolis
Arch Dermatol. 2005;141(12):1537-1541.
ABSTRACT
| FULL TEXT
Targeted UV-B Phototherapy for Plaque-type Psoriasis
Pravit Asawanonda, Akkrawat Chingchai, and Pawinee Torranin
Arch Dermatol. 2005;141(12):1542-1546.
ABSTRACT
| FULL TEXT
Dose-Response and Time-Course Characteristics of UV-A1 Erythema
Paula E. Beattie, Robert S. Dawe, James Ferguson, and Sally H. Ibbotson
Arch Dermatol. 2005;141(12):1549-1555.
ABSTRACT
| FULL TEXT
Soak and Smear: A Standard Technique Revisited
Ari Benjamin Gutman, Albert M. Kligman, Joslyn Sciacca, and William D. James
Arch Dermatol. 2005;141(12):1556-1559.
ABSTRACT
| FULL TEXT
Advances in Psoriasis
Mark G. Lebwohl
Arch Dermatol. 2005;141(12):1589-1590.
EXTRACT
| FULL TEXT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Enhancing global capacity in the surveillance, prevention, and control of chronic diseases: seven themes to consider and build upon
Choi et al.
J. Epidemiol. Community Health 2008;62:391-397.
ABSTRACT
| FULL TEXT
Smoking is negatively associated with the presence of thyroglobulin autoantibody and to a lesser degree with thyroid peroxidase autoantibody in serum: a population study
Pedersen et al.
Eur J Endocrinol 2008;158:367-373.
ABSTRACT
| FULL TEXT
Risk of myocardial infarction in patients with psoriasis.
Gelfand et al.
JAMA 2006;296:1735-1741.
ABSTRACT
| FULL TEXT
Obesity, Smoking, and Psoriasis
Lebwohl and Callen
JAMA 2006;295:208-210.
FULL TEXT
Advances in Psoriasis
Lebwohl
Arch Dermatol 2005;141:1589-1590.
FULL TEXT
|
