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Mycosis fungoides (MF), a cutaneous lymphoma with diverse clinical manifestations, rarely presents with vesiculobullous lesions, or MF bullosa (MFB). Mycosis fungoides with large cell transformation, transformed MF (T-MF), is also another rare condition. We report 2 cases of MFB, one of which was complicated with T-MF.

Report of Cases

Case 1. A 72-year-old woman, who was first diagnosed as having MF in her fifties (Figure 1A and B), presented with multiple nodules on her back (Figure 1C). Skin specimens of a nodule showed atypical cells with enlarged, pale nuclei clustered in the dermis (Figure 1D).These malignant cells stained positive for CD30. She was diagnosed as having T-MF and was treated with psoralen plus UV-A (PUVA) and topical corticosteroids.

Figure appears in full text version. Figure 1. Case 1. A, Dark reddish macules on the trunk corresponding with typical mycosis fungoides. B, A bandlike upper dermal infiltrate with epidermotropism of small atypical lymphocytes (hematoxylin-eosin, . . . [Full Text of this Article]

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AUTHOR INFORMATION
Ken Natsuga, MD; Tadamichi Shimizu, MD, PhD; Riichiro Abe, MD, PhD; Kazuo Kodama, MD; Hiroshi Shimizu, MD, PhD

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