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Harnessing Human Variation for Personalized Medicine

Anthony E. Oro, MD, PhD

Arch Dermatol. 2008;144(3):389-391.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In 2001, JAMA and its related journals published a special genomics issue at a time when the sequencing of the human genome was finishing.¹ This issue of the Archives on clinically relevant genetics and genomics comes a mere 7 years later and heralds the rapid progress in deciphering the human genome and the genetic basis of disease. This issue showcases a few of the latest advances in clinical genetics of the skin. While scientific progress opens opportunities for medical breakthroughs, it also engenders additional challenges that need to be addressed in the years to come.

HOW FAR HAVE WE COME?

Since the 2001 issue, several major advances in genomics have revolutionized our understanding of human genetics. First, both genetic and archeological data suggest that all modern humans have descended from a common ancestor who came out of Africa approximately 100 000 years ago. These studies suggest that modern humans share a . . . [Full Text of this Article]

OPPORTUNITIES
Annotation, Annotation, Annotation

Understanding the Genetic Basis of Human Variation

Toward Personalized Genetic Therapy

CHALLENGES
How to Bring Genomic Advances to Individual Patients

How to Best Administer Ethical Genetic Testing

AUTHOR INFORMATION

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