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Priti Mohan Melwani, MD; Yeray Peñate, MD; Noemi Guillermo, MD; Elena Soler, MD; Buenaventura Hernández-Machín, MD; Leopoldo Borrego, MD

Arch Dermatol. 2009;145(11):1224-1226.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

INTRODUCTION

Palmoplantar pustulosis (PPP) is a chronic inflammatory disease characterized by recurrent pustules on the palms and soles. Its etiology is unknown, and its relationship to psoriasis is not clear. Treatment of PPP can be challenging. Several immunomodulatory drugs have been used with moderate results. Herein, we report 2 cases of PPP that achieved complete remission with leflunomide.

REPORT OF A CASE

CASE 1

In 1995, a 30-year-old woman presented with a 6-day history of fever and pruritic pustules on her left hand. Physical examination revealed confluent pustules surrounded by erythema on the dorsal aspect of the left hand, palm, and wrist (Figure 1). There were no lesions in other locations. Her medical history was otherwise unremarkable.

Figure appears in full text version. Figure 1. Patient 1 prior to treatment. The dorsum of the hand has multiple confluent pustules surrounded by erythema . . . [Full Text of this Article]

CASE 2

THERAPEUTIC CHALLENGE

SOLUTION

COMMENT

AUTHOR INFORMATION

Department of Dermatology, Hospital Universitario Insular de Gran Canaria, Las Palmas de Gran Canaria, Spain

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