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Lichen Planopilaris Treated With a Peroxisome Proliferator–Activated Receptor  Agonist
Paradi Mirmirani, MD;
Pratima Karnik, PhD
Arch Dermatol. 2009;145(12):1363-1366.
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INTRODUCTION
Primary cicatricial alopecias (PCAs), rare disorders that lead to permanent hair loss, have been poorly understood and are difficult to treat. Lichen planopilaris (LPP) is a prototypical PCA; patients often present with sudden onset of hair loss and clinically significant symptoms of itching, burning, and pain of the scalp. Examination reveals patchy alopecia or a more diffuse thinning of the scalp with characteristic perifollicular erythema and perifollicular scale at the margins of the areas of alopecia. Treatment typically includes use of anti-inflammatory medications; although symptoms may improve, hair loss is often progressive.
REPORT OF A CASE
The patient, a 47-year-old white man, had sudden onset of scalp irritation, redness, and itching with rapid hair loss. Although he had long-standing male-pattern hair loss with thinning hair on the top of the scalp, he observed new hair loss involving the entire scalp. The patient had no other significant medical problems; . . . [Full Text of this Article]
THERAPEUTIC CHALLENGE
SOLUTION
COMMENT
AUTHOR INFORMATION
Departments of Dermatology, The Permanente Medical Group, Vallejo, California (Dr Mirmirani), Case Western Reserve University, Cleveland, Ohio (Drs Mirmirani and Karnik), and University of California, San Francisco (Dr Mirmirani)
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Medical and Environmental Risk Factors for the Development of Central Centrifugal Cicatricial Alopecia: A Population Study
Kyei et al.
Arch Dermatol 2011;147:909-914.
ABSTRACT
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