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Identification of Risk Factors for Psoriatic ArthritisScientific Opportunity Meets Clinical Need
Alexis Ogdie, MD;
Joel M. Gelfand, MD, MSCE
Arch Dermatol. 2010;146(7):785-788. doi:10.1001/archdermatol.2010.136
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Psoriatic arthritis (PsA) is a chronic inflammatory disease that can be progressive and may be associated with permanent joint damage and disability. Though rare in the general population, it is common in patients with psoriasis, affecting about 6% to 10% of patients with psoriasis overall and substantially more patients with more extensive skin disease (20%-40%).1-2 In most patients with PsA, the symptoms do not develop until years after the onset of cutaneous psoriasis. As a result, patients with psoriasis represent a unique opportunity to identify individuals at very high risk of developing a chronic inflammatory arthropathy (ie, PsA). To determine which patients with psoriasis are at greatest risk of developing PsA, it is essential that risk factors be identified using robust epidemiologic approaches.
Risk factors are important to identify because they may be in the causal pathway of an association; mitigation of . . . [Full Text of this Article] GENETIC RISK FACTORS
ENVIRONMENTAL RISK FACTORS
AUTHOR INFORMATION
Author Affiliations: Division of Rheumatology (Dr Ogdie) and Department of Dermatology and Center for Clinical Epidemiology and Biostatistics (Dr Gelfand), University of Pennsylvania Hospital, Philadelphia.
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