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JAMES C. FOX, JR., M.D.; GEORGE H. GILDERSLEEVE, M.D.; JOHN F. PRESTON, M.D.

Arch Derm Syphilol. 1925;11(6):768-781.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

A clinical study of the therapeutic value of a new drug is always beset with many difficulties. This is particularly true when one is dealing with a chronic infectious disease, the course of which is characterized by spontaneous remission and relapse. The literature of the last decade pertaining to the chemotherapy of syphilis reveals striking discrepancies between the opinions of different investigators in regard to the value of each new drug introduced.

Recently, since the work of Brown and Pearce¹ on syphilis in the rabbit, and especially since the utilization of the method of nodal transfer as a criterion for cure, a more exact and standardized technic for establishing the spirocheticidal value and therapeutic index of a drug has been developed. However, experimental syphilis in the rabbit and human syphilis as a potential chronic infection presenting various types of reaction between host and parasite and varying grades of response . . . [Full Text PDF of this Article]

Author Affiliations
NEW HAVEN, CONN.

From the Department of Internal Medicine, Yale University School of Medicine and the Medical Service of the New Haven Hospital.

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