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Variegate Porphyria
Harry L. Wechsler, MD
McKeesport, Pa
Arch Dermatol. 1975;111(7):926-927.
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To the Editor.—
The case of a 27-year-old woman with variegate porphyria was presented by Freinkel and Ashman to the Chicago Dermatological Society, March 21, 1973, in the ARCHIVES (110:653-654, 1974). The findings are similar to those in a 31-year-old woman whom I have been following up for the past two years. These findings include the following: development of bullae and pigmentation of the dorsa of the hands, particularly after sun exposure; episodes of abdominal distress, the history of which was originally overlooked; quantitative 24-hour urine values in which the values of the coproporphyrins exceeded those of the uroporphyrins; and absence of measurable urinary porphobilinogen. There was no history of intake of drugs or unusual amounts of alcohol. Despite a negative screening test for urinary porphobilinogen, uroporphyrins, and coproporphyrins, a quantitative 24-hour urinary porphyrin study was done because the initial clinical features were so consistent with porphyria cutanea tarda. This
. . . [Full Text PDF of this Article]
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