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Thomas K. Burnham, MB, BS (London)
Detroit

Arch Dermatol. 1976;112(1):122.

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In Reply.—

The key to the questions asked by Dr Pedro is that he has misquoted and consequently misinterpreted our statements concerning the relationship between threads and fine threads^1-3 and the two separate antibodies to extractable nuclear antigen (ENA) of Sharp et al.⁴ A serum exchange with Gordon C. Sharp, MD, showed that the pattern he reported as speckles⁴ (also referred to as such in the cooperative study on immunofluorescence tests⁵) could in fact be separated morphologically into two patterns, threads and fine threads.¹ We suggested that these two patterns might represent the two antibodies reported to be reactive with ENA.¹ Specifically, we suggested that the fine threads might possibly represent the antibody to ribonucleasesensitive ENA, seen in patients with mixed connective tissue (MCT) disease,⁴ while the threads may be produced by the antibody to ribonuclease-resistant ENA,⁶ found in patients with systemic lupus erythematosus . . . [Full Text PDF of this Article]

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