This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Richard C. Connors, MD; A. Bernard Ackerman, MD

Arch Dermatol. 1976;112(12):1767-1780.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The determination of benign or malignant nature of a neoplasm is an onerous responsibility of histopathologists. Recent advances in submicroscopy, remarkable as they are, have not spared them this momentous judgment. Histopathologists are expected to be able to predict the future biologic behavior of a neoplasm on the basis of its microscopic appearance. It is too much to always expect of them, but forced as they are to make critical decisions, the following are the essential criteria they timorously employ.

A benign neoplasm typically has parenchymal cells with nuclear and cytoplasmic characteristics that are much like those of normal cells of similar histogenesis. The neoplastic cells are uniform in configuration and orderly in arrangement. There are but few mitotic figures, and they are normal in appearance. Growth of neoplastic cells is entirely expansive, without destruction of adjacent tissue or invasion of vessels.^1-3

In contrast, the malignant neoplasm generally has . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Dermatology, New York University School of Medicine, New York.

Footnotes
Accepted for publication April 14, 1976.

Reprint requests to Skin and Cancer Unit, New York University Medical Center, 562 First Ave, New York, NY 10016 (Dr Ackerman).

CiteULike    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter     What's this?