This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (73)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Cutaneous Manifestations of Patients With Epidermal Nuclear Staining and High Titer Serum Antibody to Ribonuclease-Sensitive Extractable Nuclear Antigen

James N. Gilliam, MD; Stephen D. Prystowsky, MD

Arch Dermatol. 1977;113(5):583-587.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

• Fifteen patients with epidermal nuclear staining on direct immunofluorescence of normal skin and high titer serum antibody to ribonuclease-sensitive extractable nuclear antigen (ENA) had diffuse nonscarring and focal alopecia, abnormal pigmentation, swollen hands with sclerodactyly, and chronic cutaneous lupus erythematosus (LE) as the most common dermatologie features. Direct immunofluorescence of normal, unexposed skin revealed a particulate ("speckled") epidermal nuclear staining pattern in all 15 patients and subepidermal immunoglobulin deposits in 5. Ribonucleoprotein antibodies in high titer are associated with this characteristic type of epidermal nuclear staining. These findings provide easily detectable markers for a less aggressive subset of LE characterized by distinctive clinical and laboratory features consistent with mixde connective tissue disease.

(Arch Dermatol 113:583-587, 1977) . . . [Full Text PDF of this Article]

Author Affiliations
From the Division of Dermatology, Department of Internal Medicine, The University of Texas Southwestern Medical School, Dallas. Dr Prystowsky is now at the Letterman Army Institute of Research, San Francisco.

Footnotes
Accepted for publication June 30, 1976.

Reprint requests to 5323 Harry Hines Blvd, Dallas, 75235 (Dr Gilliam).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?