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Mycosis Fungoides With Blast Cell Transformation
Christine I. Harrington, MB, ChB, MRCP;
David N. Slater, B Med Sci, MB, ChB
Arch Dermatol. 1978;114(4):611-612.
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An unusual case of mycosis fungoides underwent apparent blast cell transformation after two years and the patient died in a leukemic state.
Report of a case
A 57-year-old man had a six-month history of raised red patches on the trunk and limbs. The clinical diagnosis of mycosis fungoides was confirmed by a skin biopsy specimen that demonstrated Daurier-Pautrier epidermal abscesses and a dermal "band-like" infiltrate of mixed mononuclear cells, including large and small hyperchromatic mycosis cells.1,2 The initial lesions responded to ultraviolet light and topical fluocinonide and new lesions that appeared after seven months were treated with cyclophosphamide, prednisolone sodium phosphate, and local radiotherapy (total 4,000 R). Eighteen months later, results of the liver function tests became abnormal and inguinal lymphadenopathy developed. Two ten-day courses of chemotherapy (cyclophosphamide, vincristine sulfate, procarbazine hydrochloride, and prednisolone) were administered, but the third course was terminated owing to the development of pancytopenia. During
. . . [Full Text PDF of this Article]
Author Affiliations
From the Rupert Hallam Department of Dermatology, Hallamshire Hospital (Dr Harrington) and the Academic Division of Pathology, University of Sheffield Medical School (Dr Slater), Sheffield, England.
Footnotes
Reprints not available.
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