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Denny L. Tuffanelli, MD

Arch Dermatol. 1982;118(10):844-845.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In the past 40 years, there have been great advances in our understanding of the bullous diseases, in general, and pemphigus, in particular. In 1943, Civatte's demonstration of acantholysis and, in 1952, Lever's separation of pemphigus diseases from pemphigoid syndromes set the stage. Then, in 1964, Beutner and Jordon¹ initially observed that serum samples from patients with pemphigus vulgaris contained an antibody that reacted with an intercellular substance of stratified squamous epithelium. Jordon, at the time, was a medical student working in Beutner's laboratory in Buffalo, NY. In their initial study, serum samples from eight of 13 patients yielded a characteristic reaction pattern when tested by indirect immunofluorescence microscopy. In addition, a biopsy specimen of normal skin adjacent to a blister of one patient with pemphigus demonstrated -globulin bound in the intercellular space. These findings were initially reported in the Proceedings of the Society for Experimental Biology and Medicine . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Dermatology, University of California, San Francisco.

Footnotes
Reprint requests for commentary to 450 Sutter St, #1306, San Francisco, CA 94108 (Dr Tuffanelli).

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