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Concepts in Transition

Eugene J. Van Scott, MD; Ruey J. Yu, PhD

Arch Dermatol. 1982;118(10):860-861.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Concepts that account for disease manifestations are necessarily seen in terms of the kind of science in vogue at the moment. At the peak of interest in the cell cycle, a decade or longer ago, patterns of mitotic replication were studied in a number of epithelial disorders. The information obtained from these studies gave a new kind of understanding to these disorders.

From time to time, it is important to reexamine all the fundamentals of a disease in an attempt to improve the prevailing concepts. A reexamination of the ichthyoses in such a framework may be timely now. Some new areas of information may provide new clues to the nature of the disorders themselves as well as to other disorders in which disturbed keratinization is a major determinant of disease expression, including such disparate diseases as dry skin, keratoses, warts, and acne.

The singular aspect of the diseases known as . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Dermatology, the Skin and Cancer Hospital, Temple University Health Sciences Center, Philadelphia.

Footnotes
Reprint requests for commentary to the Department of Dermatology, the Skin and Cancer Hospital, Temple University Health Sciences Center, 3322 N Broad St, Philadelphia, PA 19140 (Dr Van Scott).

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