This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Powerful New Tools for the Clinician

Carole L. Berger, PhD; Richard Edelson, MD

Arch Dermatol. 1982;118(9):627-629.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The recent advent of monoclonal antibodies has provided the clinician and investigator with a family of enormously powerful probes. Indeed, it seems likely that our understanding of human biology will be so substantially influenced by this new technology that the practice of medicine will require a working knowledge of it. Because the skin is so easily sampled and because that tissue contains so manydistinct types of differentiated cells and cell products, the discipline of dermatology will probably be among the most profoundly affected.

This scientific quantum jump occurred largely through serendipity. To study antibody synthesis by B cells, Kohler and Milstein¹ hybridized or fused murine normal B cells and malignant myeloma cells. These tetraploid cells were programmed by the DNA of the normal B cell to produce specific antibody and were programmed by the myeloma cell's DNA to secrete large amounts of this antibody and to proliferate into a . . . [Full Text PDF of this Article]

Author Affiliations
New York

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?