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Eruptive Neurofibromatosis Associated With Anorexia Nervosa
MAJ James E. Fitzpatrick, MC;
MAJ Michael McDermott, MC;
LTC Dennis May, MC;
COL Fred D. Hofeldt, MC
Arch Dermatol. 1983;119(12):1019-1021.
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Neurofibromatosis (Recklinghausen's disease) is a well-recognized syndrome transmitted by an autosomal dominant gene. The cutaneous and internal manifestations of the disease have been well known for almost 100 years, but little is known about its pathogenesis. Eruptive neurofibromatosis has previously been reported in association with puberty and pregnancy, suggesting that hormones or growth factors may modulate tumor growth.1,2 We report herein the development of eruptive neurofibromatosis in association with anorexia nervosa.
Report of a Case
An 18-year-old woman with known neurofibromatosis and anorexia nervosa was seen in April 1981 with a two- to three-week history of the appearance of several hundred papules on her trunk and extremities. She had been previously diagnosed as having neurofibromatosis at 2 years of age, based on the presence of multiple café au lait spots on the trunk and extremities, defective development of the orbital bones, and neurofibromas of the neck and right foot.
. . . [Full Text PDF of this Article]
Author Affiliations
USA; USA; USA; USA
From the Dermatology Service (Drs Fitzpatrick and May) and Endocrinology Service (Drs McDermott and Hofeldt), Department of Medicine, Fitzsimons Army Medical Center, Aurora, Colo.
Footnotes
The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense.
Reprint requests to Dermatology Service, Department of Medicine, Fitzsimons Army Medical Center, Aurora, CO 80045 (Dr Fitzpatrick).
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