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Jens Roar Bjerke, MD; Gunnar Haukenes, MD; John Karsten Livden, MD; Roald Matre, MD
University of Bergen Broegelmann Research Laboratory for Microbiology MFH-BYGGET, N-5016 Haukeland Sykehus Bergen, Norway Miklos Degré Oslo

Arch Dermatol. 1983;119(12):955-956.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

Increasing evidence points to the importance of immune mechanisms in the pathogenesis of psoriasis. The role of humoral v cellular immune reactions in the development of psoriatic skin lesions seems still to be open for discussion. In the September ARCHIVES (1982;118:652-657), Jablonska et al claimed that the polymorphonuclear leukocytes play an important role in the earliest stages of development of psoriatic lesions. Recently, we have obtained data indicating that lymphocytes and macrophages are involved in the pathogenesis of psoriasis.

Macrophages and T cells are regularly found in early psoriatic lesions. There is great variation in the relative proportions of these cells, depending on the clinical activity of the disease.¹ When monoclonal antibodies against T-cell surface antigens are used, both helper-inducer and suppressor-cytotoxic T cells can be demonstrated.² To determine the functional state of T cells in the psoriatic plaque, we have studied the presence of . . . [Full Text PDF of this Article]

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