This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Oscar D. Ratnoff, MD

Arch Dermatol. 1983;119(5):432-437.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Since the late 1950s, we have come to learn that many of the defenses of the body against injury are interdependent, and that such protective devices as clotting, fibrinolysis, inflammation, and immunologic reactions are not separable phenomena but rather are different facets of one intertwining mechanism. As a coagulationist, I shall support this view by focusing on what I know about an unusual clotting factor, Hageman factor, but I could equally well use as a starting point the complexities of platelet function, or complement, or the systems that generate biologically active polypeptides such as bradykinin.

For two centuries, investigators have marveled that blood, fluid within our vessels, clots when it is shed. About 100 years ago, John Lister,¹ better known for other things, made the remarkable observation that shed blood clotted much faster in a porcelain dish than in an india-rubber tube. His very modern conclusion was that clotting . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Medicine, Case Western Reserve University School of Medicine, and University Hospitals of Cleveland. Dr Ratnoff is a Career Investigator of the American Heart Association.

Footnotes
Accepted for publication Oct 26, 1982.

Reprint requests to University Hospitals of Cleveland, Cleveland, OH 44106 (Dr Ratnoff).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?