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G. E. WAKERLIN, M.S.; P. H. CARROLL

Arch Derm Syphilol. 1925;12(5):670-678.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The reliability of the blood Wassermann reaction in experimental rabbit syphilis has long been the subject of controversy. Blumenthal and other German workers, using alcohol-soluble antigen and inactivated serum, found that normal rabbits not infrequently reacted positively. By modifying the quantities of antigen and serum used, Blumenthal¹ obtained uniformly negative results with nonsyphilitic rabbits but inconsistent results with syphilitic animals. Halberstaedter² reported negative results in normal rabbits with alcoholic-extract antigen and active serum, but Uhlenhuth and Mulzer³ failed to confirm his findings. On the other hand, Nichols,⁴ using alcohol-soluble antigen and inactivated serum, found normal rabbits negative and syphilitic rabbits positive. Kolmer and Casselman⁵ showed an increased tendency to positive reactions in normal rabbits as larger amounts of inactivated serum were used. Emanuel⁶ and Epstein and Pribram⁷ stated that the positive blood Wassermann reaction of normal rabbits could be negated temporarily by . . . [Full Text PDF of this Article]

Author Affiliations
MADISON, WIS.

From the Department of Pharmacology, University of Wisconsin and the Wisconsin Psychiatric Institute.

Footnotes
This research is a part of an extended investigation in progress in the Department of Pharmacology, University of Wisconsin, and the Wisconsin Psychiatric Institute under the general direction of Drs. A. S. Loevenhart and W. F. Lorenz on the development of new remedies for the treatment of syphilis of the central nervous system.

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