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Colchicine Therapy in Recurrent Oral Ulcers
Albert Gatot, MD;
Ferit Tovi, MD
Ear, Nose, and Throat Department Soroka Medical Center PO Box 151 Beer-Sheva 84101, Israel
Arch Dermatol. 1984;120(8):994.
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To the Editor.—
During the past two decades, colchicine has been shown to be effective in treating a wide variety of inflammatory disorders, including the cutaneous lesions of Behçet's disease.1 As there is no clear-cut distinction between recurrent oral ulcers or so-called aphthous stomatitis and the mucosal involvement in Behçet's disease,2 we used colchicine therapy in four cases of protracted aphthous stomatitis.
Report of Cases.—CASE 1.—
A 32-year-old woman had a long history of recurrent ulceration of the mouth during every menstrual period. Following a prodromal phase of soreness and burning sensation for one to two days, two or three small aphthous ulcers appeared, causing pain for ten days. Oral colchicine, 0.6 mg/day, was administered for a month, with no recurrence of the ulcers during the subsequent menstrual period. However, the patient complained of nausea after one month of therapy, so we limited administration of the
. . . [Full Text PDF of this Article]
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