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Raymond L. Barnhill, MD, MSc; Neal S. Penneys, MD, PhD; Debra Landau-Price, MD; M. Nadji, MD; Jocelyn Ziegels-Weissman, PhD; Shinobu Matsuo, MD
Departments of Dermatology and Pathology University of Miami School of Medicine Miami, FL 33101; Department of Dermatology Asahikawa Medical College Hokkaido, Japan

Arch Dermatol. 1985;121(2):169-170.

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To the Editor.—

The infiltration of mature fat cells among intradermal nevus cells in melanocytic nevi is a relatively common event and correlates with age.¹ Nonetheless, the origin of these cells is uncertain. Various hypotheses for this fatty infiltration have included (1) presence of nevus lipomatosus in melanocytic nevi,¹ (2) fatty metamorphosis of nevus cells,^2,3 and (3) development of fat cells from mesenchymal elements.¹ Since nevus lipomatosus is usually a congenital lesion and the age of patients with melanocytic nevi that contain fat is usually greater than 50 year s,¹ the first explanation is unlikely. With regard to the second possibility, Maize and Foster² could find no evidence histologically of transition from nevus cells to lipocytes, making this interpretation less credible.

S100 protein is an acidic calcium-binding protein that is found in neuroepithelium. In the skin, this substance is found within melanocytes, Schwann's cells, Langerhans' . . . [Full Text PDF of this Article]

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