This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Jean-Claude Roujeau, MD; Jean-Claude Guillaume, MD; Jean Revuz, MD; René Touraine, MD; Mathieu Kuentz, MD
Department of Dermatology; Department of Hematology Hopital Henri Mondor Université Paris Val de Marne 94010 Creteil, France

Arch Dermatol. 1985;121(3):305.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

As the medical staff of an intensive care unit for severe skin diseases, we were disturbed by the article by Westly and Wechsler¹ about granulocytic leukopenia in ten patients with toxic epidermal necrolysis (TEN).¹ Our own findings about hematologic alterations in 26 TEN patients have been recently published.² There is a lot of discordance between the two studies.

Eleven of our 26 patients had a decreased white blood cell (WBC) count (<4,000/cu mm), but in eight cases this leukopenia resulted from a lymphopenia and not from a granulocytopenia. Only three of 26 patients had a granulocytopenia, with granulocyte counts below 1,500/cu mm, three to nine days after the beginning of a drug-induced TEN. Two of these three patients had a bone marrow aspiration showing alterations of the myeloid lineage suggestive of drug toxicity. Similar alterations in the myeloid lineage were seen in two of . . . [Full Text PDF of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?