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Minna Mörtenhumer, MD; Aarne Oikarinen, MD
Department of Dermatology University of Oulu 90220 Oulu Finland

Arch Dermatol. 1985;121(8):971.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

The application schedule of potent glucocorticosteroids is important for several reasons. These steroids are widely used for treatment of various dermatoses, and potent glucocorticosteroids have adverse side effects, such as atrophy¹ and tachyphylaxis.² Thus, it is important to optimize the application schedule to get maximum clinical effect with minimal side effects.

Du Vivier et al³ reported that, in mouse skin, the application of a glucocorticosteroid once every other day resulted in marked suppression of epidermal cell DNA synthesis and that the application of a steroid twice daily was not more effective. Their results suggest that, in clinical practice, one application of a glucocorticosteroid on alternate days is as effective as an application twice a day. We performed a clinical trial in psoriatic patients using both regimens.

Patients and Methods.—

Twenty-nine inpatients with psoriasis were randomly selected for participation in the trial; 28 had psoriasis . . . [Full Text PDF of this Article]

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