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Richard B. Stoughton, MD; Roger C. Cornell, MD
Department of Dermatology School of Medicine MO23C University of California, San Diego La Jolla, CA 92093; Division of Dermatology Scripps Clinic and Research Foundation 10666 N Torrey Pines Rd La Jolla, CA 92037

Arch Dermatol. 1985;121(9):1105.

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In Reply.—

The "area-under-the-curve" method is a perfectly rational one, reported by others. The main problem is to correlate vasoconstriction data with clinical data, and this we have done with our method (16 hours under a guard, one reading). Other methods will have to be checked with clinical data to see if they are predictive. Our data are the most comprehensive for a single method. It would be very interesting to look at alclometasone and hydrocortisone valerate with the area-under-the-curve method.

Other workers have shown that extemporaneous formulations are unpredictable in their clinical activity, and we avoid them for that reason.

Triamcinolone acetonide is available in many different ointment, cream, and lotion vehicles in this country. The old conventional ointments were more biologically active than the creams, but there have been so many alterations, especially in the creams, that one can no longer set any predictive rules for ointments or creams . . . [Full Text PDF of this Article]

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