This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on Web of Science (7)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

R. P. C. Naik, MD; C. R. Srinivas
Department of Dermatology P. C. Das, MD Department of Pathology Kasturba Medical College and Hospital Manipal 576 119, India

Arch Dermatol. 1986;122(5):509-510.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

We have noted a widespread allergic drug reaction that spared lesional skin of nevus depigmentosus.

Report of a Case.—

A 45-year-old epileptic who was receiving phenobarbital sodium therapy for three months developed a generalized erythematous macular and papular rash. The eruption started on the dorsal aspect of the feet and rapidly became generalized. A hypopigmented macula (about 2 cm in diameter) located on the right pectoral region was spared. The pale macula, present since birth, was diagnosed as nevus depigmentosus. Biopsy specimens taken from the macula and the adjacent eruption were subjected to hematoxylin-eosin and Masson-Fontana staining. A superficial mononuclear infiltrate around dilated vessels that were seen in the eruption was absent in the area of the nevus depigmentosus. Melanization was partial in the depigmented skin compared with the skin affected by the drug rash.

Comment.—

Predilection for certain sites is characteristic of some dermatoses. Similarly, sparing . . . [Full Text PDF of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?