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Benjamin Moncada, MD; Manuel Sandoval, MD; Roberto Gonzalez Amaro, MD; Antonio Torres-Ruvalcaba, MD
Facultad de Medicina University Autonoma de San Luis Potosi Avenue Via Carranza 2405 Apdo Postal 142 CP 78210 San Luis Potosi, Mexico

Arch Dermatol. 1987;123(10):1267-1268.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

Vitiligo may belong to the category of autoimmune diseases since a great proportion of patients have circulating antimelanocytic antibodies.¹ However, other components of the immune system might be involved as well, as it is suggested by the work of Hatchome et al² who reported a weaker hypersensitivity response to dinitrochlorobenzene in vitiliginous skin compared with uninvolved skin. They also reported a normal number of epidermal Langerhans' cells (LCs) in vitiliginous skin. However, contrary to their findings, we observed increased numbers of LCs in vitiliginous skin compared with normal skin of matched controls.

We studied lesions from ten patients with vitiligo by indirect immunofluorescence using OKT6 monoclonal antibody.³ Our results (Table) show a significant increase in the content of LCs in involved skin of patients with vitiligo compared with normal matched controls (P <.001).

Before the advent of monoclonal antibodies, it was believed that the . . . [Full Text PDF of this Article]

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