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Dallas Paraskevas, MSc; Dimitris Rekkas, PhD; Nicolaos Choulis, PhD; John Hatzis, MD; John Stratigos, MD
Department of Pharmaceutical Technology; Department of Dermatology and Venereology University of Athens 10 Polytechniou St 10433 Athens, Greece

Arch Dermatol. 1987;123(11):1433-1435.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

In this study, the in vitro release of minoxidil from creams and lotions (which appear in the literature for the treatment of several forms of alopecia) was studied. The release of the drug from the creams was found to be 50% less than its release from the lotions. The release profile of minoxidil was similar for all the lotions that were examined. There was no significant difference between the release of the drug from the creams. A formulation of minoxidil prepared with propylene glycol:water:ethanol (15:15:70) is suggested for topical use, especially when the drug is available from tablets only.

Topically applied minoxidil has been used recently for the treatment of alopecia areata and malepattern alopecia.^1-3 Several formulations of minoxidil have been suggested for topical use that are prepared today by the pharmacist. These pharmaceutical preparations have not been tested comparatively with respect to the drug being . . . [Full Text PDF of this Article]

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