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Yoshihiro Maekawa, MD; Toshitatsu Nogita, MD; Masanobu Yamada, MD
Department of Dermatology Kumamoto University Medical School Kumamoto 860, Japan

Arch Dermatol. 1987;123(11):1440-1441.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

Progressive systemic sclerosis (PSS) is a multisystem disease characterized by fibrosis of the skin and of internal organs such as the esophagus. The fibrosis of PSS may be associated with excessive accumulation of collagen. Its cause is unknown, although the detection of autoantibodies has suggested an autoimmune disease.¹ Thivolet et al² and Delbarre et al³ reported systemic improvement of patients with PSS who received blood coagulation factor XIII (factor XIII). They attributed this benefit to the removal of the excess collagen by factor XIII. We gave factor XIII to two patients with PSS and obtained interesting results.

Report of Cases.—

Two patients with a generalized type of PSS, a 71-year-old woman in Japan (case 1) and a 26-year-old woman (case 2), were, respectively, given factor XIII, in daily doses of 480 U in an intravenous drip infusion for three weeks.

To determine the effect . . . [Full Text PDF of this Article]

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