This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Constance Marjorie Ridley, MA, BM, BCh, FRCP

Arch Dermatol. 1987;123(4):457-460.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

A comprehensive account of this many-faceted and fascinating disease could be of formidable length. I shall review a few aspects of particular interest, especially those that raise questions as yet unanswered. More detailed discussion and references can be found elsewhere.^1,2

ETIOLOGY

The article by Shirer and Ray in this issue of the ARCHIVES comments on familial incidence; one such recent and striking report³ is of lichen sclerosus et atrophicus (LSA) at the vulva in identical twin girls of HLA types A2/3, B7/60, and C3/7. Although the evidence linking LSA with HLA types is at present somewhat confusing, these findings suggest that there is a significance awaiting elucidation. Strange, too, is the link with autoimmune disease,^4-6 and the fact that when the link is present it confers no particular pattern on the clinical manifestations. Apart from the suggestion that some local anomaly of sex-hormone metabolism is involved, some . . . [Full Text PDF of this Article]

Author Affiliations
Elizabeth Garrett Anderson Hospital Euston Road London NW1 2AP, England

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?