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Fred J. McIlreath, PhD
Research Department Reed & Carnrick 1 New England Ave Piscataway, NJ 08855

Arch Dermatol. 1988;124(12):1868-1869.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor. —

In In his letter, published in the March 1988 issue of the ARCHIVES, Solomon¹ questioned whether the optimal dose of lindane had been established. It is true that lindane is sold in Europe as a 0.3% solution. However, in our entomology laboratory, we tested the effectiveness of various concentrations of lindane in killing laboratorybred lice. We found that as the concentration dropped below 1.0% so too did the pediculicidal activity, precipitously so when the concentration reached 0.33% (Figure). This may explain why most of the reports of lindane resistance have come from Europe, where, probably, a sublethal concentration is used.

Solomon also suggests that potential toxicity to lindane could be reduced by assuring that the lotion is washed off at a specified time. Examination of the report by Ginsburg et al² demonstrates that this would probably not achieve the intended goal. In their study, a lindane lotion was applied to the entire body of scabetic infants and children . . . [Full Text PDF of this Article]

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