This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Citing articles on Web of Science (18)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

David A. Fisher, MD; Peter M. Elias, MD; Philip L. LeBoit, MD
Departments of Dermatology and Pathology University of California, San Francisco, School of Medicine San Francisco, CA 94143

Arch Dermatol. 1988;124(6):854-855.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

Elicitation or exacerbation of psoriasis has occurred following administration of the psychopharmacologic agents,¹ β-blockers,² nonsteroidal anti-inflammatory agents,³ antimalarials,⁴ isotretinoin,⁵ and chlorthalidone.⁶ Abel and coworkers⁷ have extensively analyzed and discussed the entire subject of drug-induced psoriasis in an excellent recent review.

We report herein a case of psoriasis exacerbated by gemfibrozil, a hypolipidemic fibric acid derivative, in the same category as clofibrate. Gemfibrozil decreases production of very-low-density lipoprotein (VLDL) triglycerides and enhances its clearance, but does not decrease plasma cholesterol.⁸ It does, however, increase high-density lipoprotein (HDL) cholesterol levels.^8,9 Its mechanism of action, as discussed below, is unclear.⁸ There are no previous reports of psoriasis exacerbated by gemfibrozil (Lopid, Parke-Davis). Moreover, a recent computer search by the American Academy of Dermatology Adverse Drug Reporting Center (Evanston, Ill) failed to reveal any prior reports of this phenomenon.

Report of . . . [Full Text PDF of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?