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Current Status and Future Directions

Elliott Foucar, MD; Juan Rosai, MD; Ronald F. Dorfman, MD, FRCPath

Arch Dermatol. 1988;124(8):1211-1214.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In the present issue of the ARCHIVES, Suster et al¹ describe a 72-year-old woman with large soft-tissue masses that spontaneously disappeared over a period of several weeks. In spite of the absence of lymphadenopathy, the authors cautiously suggest the diagnosis sinus histiocytosis with massive lymphadenopathy (SHML) (Rosai-Dorfman disease), based primarily on the biopsy finding of a certain cytologic subtype of S100-positive histiocytes exhibiting lymphocytophagocytosis. It is appropriate to ask just how reliable these morphological and immunologic features are in segregating a specific disease entity. If the findings are reliable, what is our current understanding of the clinical and pathologic features of this disease, how is it related to other "histiocytoses," and what are the major directions for investigation of this disease?

Histopathologic observations are currently used to subclassify many disease processes that are associated with proliferation of lymphoid and histiocytic cell lines, although immunophenotypic and immunogenotypic studies . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Pathology, Presbyterian Hospital, and the Departments of Pathology and Dermatology, University of New Mexico School of Medicine, Albuquerque (Dr Foucar), the Department of Pathology, Yale University School of Medicine, New Haven, Conn (Dr Rosai), and the Department of Pathology, Stanford (Calif) University Medical School (Dr Dorfman).

Footnotes
Accepted for publication May 3, 1988.

Reprint requests to Department of Pathology, Yale University School of Medicine, 310 Cedar St, PO Box 3333, New Haven, CT 06510-8070 (Dr Rosai).

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