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Interactions Between Epidermal Cytokines, Adhesion Molecules, and Leukocytes

Thomas S. Kupper, MD

Arch Dermatol. 1989;125(10):1406-1412.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

How do T cells find their way to the epidermis? Ever since a special relationship between T cells and epidermis was first postulated, it has been assumed that T-cell trafficking through skin occurs as a matter of course, and that the exaggeration of this process may explain the histopathologic features of many diseases characterized by T-cell infiltration of skin.^1,2 However, the molecular basis for the affinity of T cells (and, indeed, of other bone marrow-derived leukocytes) for epidermis has remained obscure. Recently, several groups have contributed an important piece to the T cell-epidermis puzzle by focusing on the role of a group of glycoproteins collectively called adhesion molecules.^3-6 Many of these molecules are members of the integrin family of proteins (based on molecular relationships), which, in turn, are thought to belong to the immunoglobulin gene superfamily.⁷ The integrins are a heterogeneous group of proteins that appear to . . . [Full Text PDF of this Article]

Author Affiliations
Division of Dermatology Washington University School of Medicine 660 S Euclid Ave St Louis, MO 63110

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