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Normal Variants or Melanoma Precursors?

George F. Murphy, MD; Allan Halpern, MD

Arch Dermatol. 1990;126(4):519-522.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The dysplastic nevus (DN) is perhaps the most controversial neoplasm in the practice of dermatology and pathology. Critics question whether it exists; if it exists, by what criteria it should be defined; and if it can be defined, whether its occurrence is of any biological significance. Proponents suggest that it may represent a paradigm for the evolutionary sequence of all neoplasia. In the present issue of the ARCHIVES, Rhodes et al¹ and Edwards et al² utilize the concept of DN to enlarge on the potential of the histologic features associated with DN to correlate with malignant degeneration and to evaluate topical treatment with tretinoin, respectively. Piepkorn,³ on the other hand, argues that the histologic features attributed to DN merely represent the pattern of benign nevi in active or hyperplastic phases of radial growth. Interpretation of such data is hindered by confusion with respect to precise histologie definitions and . . . [Full Text PDF of this Article]

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