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Peter M. Elias, MD; Mary L. Williams, MD
Dermatology Service (190) Fort Miley Veterans Affairs Medical Center 4150 Clement St San Francisco, CA 94121

Arch Dermatol. 1991;127(11):1728.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In Reply.—

In their comments on our earlier editorial,¹ Küster et al provide further valuable information that may help to resolve the issue regarding the endogenous-vs-exogenous origin of epidermal n-alkanes. They now provide biochemical data on two phenotypic subgroups of autosomal recessive ichthyosis, which do not differ in their content of n-alkanes, although the alkane content of both subsets was greater than the normal subsets. We agree with the authors that photodensitometric quantitation underestimates n-alkanes of shorter chain lengths due to the volatilization of shorter chain n-alkanes during the charring procedure. Since approximately half of scale n-alkanes will have a chain length less than or equal to C25,² the true values for n-alkanes in both of their subgroups as well as in their normal subgroups are likely to be considerably higher. Thus, we believe that laboratories that rely solely on photodensitometry . . . [Full Text PDF of this Article]

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