• Online Features  This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (21)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Use of Antimalarial Agents as Adjuvant Therapy

Sharon R. Hymes, MD; Robert E. Jordon, MD

Arch Dermatol. 1992;128(11):1462-1464.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

REPORT OF CASES

Case 1.—

A 63-year-old woman presented with a 6-year history of extensive, crusted plaques on her face, trunk, and neck. She noted exacerbations after exposure to sunlight. A lesional biopsy specimen demonstrated a cleft containing acantholytic cells in the stratum granulosum. Direct immunofluorescence was remarkable for characteristic high epidermal intercellular substance deposits of IgG and C3. Pemphigus antibody was detectable by indirect immunofluorescence at a titer of 1:80. Prednisone therapy (100 mg/d) did not control the skin lesions, and therapy was complicated by severe emotional lability and glaucoma. Intramuscular gold therapy was initiated briefly but discontinued because of hematuria. Azathioprine (150 mg/d) was added to her therapy, and the prednisone dose was gradually tapered to 80 mg, alternating with 20 mg with incomplete disease control. Subsequently, azathioprine therapy was discontinued, and hydroxychloroquine therapy (200 mg twice daily) was initiated. Within 2 months, the frequency of new lesions . . . [Full Text PDF of this Article]

CiteULike    Connotea    Delicious    Digg    Facebook    Reddit    Technorati    Twitter     What's this?