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Thomas J. Flotte, MD

Arch Dermatol. 1992;128(2):252-253.

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Immunodermatopathology began with the description of the lupus band test by Burnham et al¹ in 1963. The following year, Beutner and Jordon² demonstrated the presence of autoantibodies in serum samples of patients with pemphigus vulgaris. Thus, the two most widely used techniques, direct and indirect immunofluorescence, were described very early in the development of the field. The other three generally available techniques include complement fixation indirect immunofluorescence (a method of amplification of the antigen staining that is most widely used in herpes gestationis), immunoelectron microscopy (generally restricted to research applications), and immunoperoxidase (most widely used for tumor antigen localization and for determining the anatomic level of bullous lesions in the skin). These immunologic diagnostic techniques have become the standard modalities of definitively confirming the diagnoses of antibody mediated (or associated) diseases. Research utilizing these antibodies and techniques continues to yield information regarding the pathophysiology of various diseases. The diagnostic . . . [Full Text PDF of this Article]

Author Affiliations
Departments of Dermatology and Pathology Massachusetts General Hospital Boston, MA 02114

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